Diazepam and its metabolites are excreted generally within the urine, predominantly as their glucuronide conjugates. The clearance of diazepam is twenty to 30 mL/min in young Grown ups. Diazepam accumulates on various dosing and There's some proof which the terminal elimination 50 %-lifestyle is

Rebound stress, extra serious than baseline panic, is likewise a typical withdrawal symptom when discontinuing diazepam or other benzodiazepines.[seventy nine] Diazepam is thus only proposed for brief-term therapy at the lowest doable dose owing to dangers of severe withdrawal complications from red